Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection
Identifieur interne : 000356 ( 2020/Analysis ); précédent : 000355; suivant : 000357Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection
Auteurs : Emmie De Wit ; Friederike Feldmann ; Jacqueline Cronin ; Robert Jordan ; Atsushi Okumura ; Tina Thomas ; Dana Scott ; Tomas Cihlar ; Heinz FeldmannSource :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2020.
Descripteurs français
- KwdFr :
- AMP (analogues et dérivés), AMP (pharmacologie), Alanine (analogues et dérivés), Alanine (pharmacologie), Animaux, Antiviraux (pharmacologie), Charge virale, Coronavirus du syndrome respiratoire du Moyen-Orient (), Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie), Infections à coronavirus (), Infections à coronavirus (traitement médicamenteux), Macaca mulatta, Modèles animaux de maladie humaine, Mâle, Pandémies, Pneumopathie virale, Poumon (anatomopathologie), Poumon (virologie), Prophylaxie après exposition, Réplication virale ().
- MESH :
- analogues et dérivés : AMP, Alanine.
- anatomopathologie : Poumon.
- pharmacologie : AMP, Alanine, Antiviraux.
- physiologie : Coronavirus du syndrome respiratoire du Moyen-Orient.
- traitement médicamenteux : Infections à coronavirus.
- virologie : Poumon.
- Animaux, Charge virale, Coronavirus du syndrome respiratoire du Moyen-Orient, Infections à coronavirus, Macaca mulatta, Modèles animaux de maladie humaine, Mâle, Pandémies, Pneumopathie virale, Prophylaxie après exposition, Réplication virale.
English descriptors
- KwdEn :
- Adenosine Monophosphate (analogs & derivatives), Adenosine Monophosphate (pharmacology), Alanine (analogs & derivatives), Alanine (pharmacology), Animals, Antiviral Agents (pharmacology), Betacoronavirus, Coronavirus Infections (drug therapy), Coronavirus Infections (prevention & control), Disease Models, Animal, Lung (pathology), Lung (virology), Macaca mulatta, Male, Middle East Respiratory Syndrome Coronavirus (drug effects), Middle East Respiratory Syndrome Coronavirus (physiology), Pandemics, Pneumonia, Viral, Post-Exposure Prophylaxis, Viral Load, Virus Replication (drug effects).
- MESH :
- chemical , analogs & derivatives : Adenosine Monophosphate, Alanine.
- chemical , pharmacology : Adenosine Monophosphate, Alanine, Antiviral Agents.
- drug effects : Middle East Respiratory Syndrome Coronavirus, Virus Replication.
- drug therapy : Coronavirus Infections.
- pathology : Lung.
- physiology : Middle East Respiratory Syndrome Coronavirus.
- prevention & control : Coronavirus Infections.
- virology : Lung.
- Animals, Betacoronavirus, Disease Models, Animal, Macaca mulatta, Male, Pandemics, Pneumonia, Viral, Post-Exposure Prophylaxis, Viral Load.
Abstract
Middle East Respiratory Syndrome, caused by the MERS coronavirus (MERS-CoV), continues to cause severe respiratory disease with a high case fatality rate. To date, potential antiviral treatments for MERS-CoV have shown limited efficacy in animal studies. Here, we tested the efficacy of the broad-acting antiviral remdesivir in the rhesus macaque model of MERS-CoV infection. Remdesivir reduced the severity of disease, virus replication, and damage to the lungs when administered either before or after animals were infected with MERS-CoV. Our data show that remdesivir is a promising antiviral treatment against MERS that could be considered for implementation in clinical trials. It may also have utility for related coronaviruses such as the novel coronavirus 2019-nCoV emerging from Wuhan, China.
Url:
DOI: 10.1073/pnas.1922083117
PubMed: 32054787
PubMed Central: 7104368
Affiliations:
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PMC:7104368Le document en format XML
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sortKey="Cronin, Jacqueline" sort="Cronin, Jacqueline" uniqKey="Cronin J" first="Jacqueline" last="Cronin">Jacqueline Cronin</name><affiliation><nlm:aff id="aff1">Laboratory of Virology, National Institute of Allergy and Infectious Diseases,<institution>NIH</institution>, Hamilton,<addr-line>MT</addr-line> 59840;</nlm:aff></affiliation></author><author><name sortKey="Jordan, Robert" sort="Jordan, Robert" uniqKey="Jordan R" first="Robert" last="Jordan">Robert Jordan</name><affiliation><nlm:aff id="aff3">Biology Department,<institution>Gilead Sciences</institution>, Foster City,<addr-line>CA</addr-line> 94404;</nlm:aff></affiliation></author><author><name sortKey="Okumura, Atsushi" sort="Okumura, Atsushi" uniqKey="Okumura A" first="Atsushi" last="Okumura">Atsushi Okumura</name><affiliation><nlm:aff id="aff4">Center for Infection and Immunity, Mailman School of Public Health,<institution>Columbia University</institution>, New York,<addr-line>NY</addr-line> 10032</nlm:aff></affiliation></author><author><name sortKey="Thomas, Tina" sort="Thomas, Tina" uniqKey="Thomas T" first="Tina" last="Thomas">Tina Thomas</name><affiliation><nlm:aff id="aff1">Laboratory of Virology, National Institute of Allergy and Infectious Diseases,<institution>NIH</institution>, Hamilton,<addr-line>MT</addr-line> 59840;</nlm:aff></affiliation></author><author><name sortKey="Scott, Dana" sort="Scott, Dana" uniqKey="Scott D" first="Dana" last="Scott">Dana Scott</name><affiliation><nlm:aff id="aff2">Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases,<institution>NIH</institution>, Hamilton,<addr-line>MT</addr-line> 59840;</nlm:aff></affiliation></author><author><name sortKey="Cihlar, Tomas" sort="Cihlar, Tomas" uniqKey="Cihlar T" first="Tomas" last="Cihlar">Tomas Cihlar</name><affiliation><nlm:aff id="aff3">Biology Department,<institution>Gilead Sciences</institution>, Foster City,<addr-line>CA</addr-line> 94404;</nlm:aff></affiliation></author><author><name sortKey="Feldmann, Heinz" sort="Feldmann, Heinz" uniqKey="Feldmann H" first="Heinz" last="Feldmann">Heinz Feldmann</name><affiliation><nlm:aff id="aff1">Laboratory of Virology, National Institute of Allergy and Infectious Diseases,<institution>NIH</institution>, Hamilton,<addr-line>MT</addr-line> 59840;</nlm:aff></affiliation></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="ISSN">0027-8424</idno><idno type="eISSN">1091-6490</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenosine Monophosphate (analogs & derivatives)</term><term>Adenosine Monophosphate (pharmacology)</term><term>Alanine (analogs & derivatives)</term><term>Alanine (pharmacology)</term><term>Animals</term><term>Antiviral Agents (pharmacology)</term><term>Betacoronavirus</term><term>Coronavirus Infections (drug therapy)</term><term>Coronavirus Infections (prevention & control)</term><term>Disease Models, Animal</term><term>Lung (pathology)</term><term>Lung (virology)</term><term>Macaca mulatta</term><term>Male</term><term>Middle East Respiratory Syndrome Coronavirus (drug effects)</term><term>Middle East Respiratory Syndrome Coronavirus (physiology)</term><term>Pandemics</term><term>Pneumonia, Viral</term><term>Post-Exposure Prophylaxis</term><term>Viral Load</term><term>Virus Replication (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>AMP (analogues et dérivés)</term><term>AMP (pharmacologie)</term><term>Alanine (analogues et dérivés)</term><term>Alanine (pharmacologie)</term><term>Animaux</term><term>Antiviraux (pharmacologie)</term><term>Charge virale</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient ()</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie)</term><term>Infections à coronavirus ()</term><term>Infections à coronavirus (traitement médicamenteux)</term><term>Macaca mulatta</term><term>Modèles animaux de maladie humaine</term><term>Mâle</term><term>Pandémies</term><term>Pneumopathie virale</term><term>Poumon (anatomopathologie)</term><term>Poumon (virologie)</term><term>Prophylaxie après exposition</term><term>Réplication virale ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Adenosine Monophosphate</term><term>Alanine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Adenosine Monophosphate</term><term>Alanine</term><term>Antiviral Agents</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>AMP</term><term>Alanine</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term><term>Virus Replication</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lung</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>AMP</term><term>Alanine</term><term>Antiviraux</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Lung</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Betacoronavirus</term><term>Disease Models, Animal</term><term>Macaca mulatta</term><term>Male</term><term>Pandemics</term><term>Pneumonia, Viral</term><term>Post-Exposure Prophylaxis</term><term>Viral Load</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Charge virale</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Infections à coronavirus</term><term>Macaca mulatta</term><term>Modèles animaux de maladie humaine</term><term>Mâle</term><term>Pandémies</term><term>Pneumopathie virale</term><term>Prophylaxie après exposition</term><term>Réplication virale</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Significance</title><p>Middle East Respiratory Syndrome, caused by the MERS coronavirus (MERS-CoV), continues to cause severe respiratory disease with a high case fatality rate. To date, potential antiviral treatments for MERS-CoV have shown limited efficacy in animal studies. Here, we tested the efficacy of the broad-acting antiviral remdesivir in the rhesus macaque model of MERS-CoV infection. Remdesivir reduced the severity of disease, virus replication, and damage to the lungs when administered either before or after animals were infected with MERS-CoV. Our data show that remdesivir is a promising antiviral treatment against MERS that could be considered for implementation in clinical trials. It may also have utility for related coronaviruses such as the novel coronavirus 2019-nCoV emerging from Wuhan, China.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Modjarrad, K" uniqKey="Modjarrad K">K. Modjarrad</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brende, B" uniqKey="Brende B">B. Brende</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lo, M K" uniqKey="Lo M">M. K. Lo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Warren, T K" uniqKey="Warren T">T. K. Warren</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lo, M K" uniqKey="Lo M">M. K. Lo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sheahan, T P" uniqKey="Sheahan T">T. P. Sheahan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sheahan, T P" uniqKey="Sheahan T">T. P. Sheahan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Agostini, M L" uniqKey="Agostini M">M. L. Agostini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Wit, E" uniqKey="De Wit E">E. de Wit</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hui, D S" uniqKey="Hui D">D. S. Hui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Assiri, A" uniqKey="Assiri A">A. Assiri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, J F" uniqKey="Chan J">J. F. Chan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Z" uniqKey="Chen Z">Z. Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Wit, E" uniqKey="De Wit E">E. de Wit</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Falzarano, D" uniqKey="Falzarano D">D. Falzarano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Doremalen, N" uniqKey="Van Doremalen N">N. van Doremalen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Al Abdely, H M" uniqKey="Al Abdely H">H. M. Al-Abdely</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bin, S Y" uniqKey="Bin S">S. Y. Bin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Prescott, J" uniqKey="Prescott J">J. Prescott</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dornemann, J" uniqKey="Dornemann J">J. Dörnemann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jacobs, M" uniqKey="Jacobs M">M. Jacobs</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mulangu, S" uniqKey="Mulangu S">S. Mulangu</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Falzarano, D" uniqKey="Falzarano D">D. Falzarano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brining, D L" uniqKey="Brining D">D. L. Brining</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Corman, V M" uniqKey="Corman V">V. M. Corman</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Cihlar, Tomas" sort="Cihlar, Tomas" uniqKey="Cihlar T" first="Tomas" last="Cihlar">Tomas Cihlar</name><name sortKey="Cronin, Jacqueline" sort="Cronin, Jacqueline" uniqKey="Cronin J" first="Jacqueline" last="Cronin">Jacqueline Cronin</name><name sortKey="De Wit, Emmie" sort="De Wit, Emmie" uniqKey="De Wit E" first="Emmie" last="De Wit">Emmie De Wit</name><name sortKey="Feldmann, Friederike" sort="Feldmann, Friederike" uniqKey="Feldmann F" first="Friederike" last="Feldmann">Friederike Feldmann</name><name sortKey="Feldmann, Heinz" sort="Feldmann, Heinz" uniqKey="Feldmann H" first="Heinz" last="Feldmann">Heinz Feldmann</name><name sortKey="Jordan, Robert" sort="Jordan, Robert" uniqKey="Jordan R" first="Robert" last="Jordan">Robert Jordan</name><name sortKey="Okumura, Atsushi" sort="Okumura, Atsushi" uniqKey="Okumura A" first="Atsushi" last="Okumura">Atsushi Okumura</name><name sortKey="Scott, Dana" sort="Scott, Dana" uniqKey="Scott D" first="Dana" last="Scott">Dana Scott</name><name sortKey="Thomas, Tina" sort="Thomas, Tina" uniqKey="Thomas T" first="Tina" last="Thomas">Tina Thomas</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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